Manuel Lanzini (£5.9m) proved to be the match-winner for the Hammers and claimed two bonus points in the process.
His second-half strike was his eighth of the season and was accompanied by three completed dribbles and four key passes as the Argentinian sparkled for the hosts.
Deployed in a three-man defence, the centre-back was a dominant figure, contributing 14 clearances, blocks and interceptions (CBI) along with five recoveries.
Lanzini's performance was recognised in the ICT Index, with the playmaker top scoring for both Threat (46) and Creativity (50).
He completed 14 passes in the final third, creating four scoring chances and firing three shots of his own, two from inside the Spurs penalty area.
Lanzini's score of 14.0 in the Index overall was his third successive double-figure tally.
Christian Eriksen (£8.9m) ranked second in the Index as Spurs' top scorer for Creativity (38).
The Dane succeeded with three of 12 attempted crosses, supplying three chances for the visitors.
Harry Kane (£11.7m) went into Friday's derby backed by 92,000 new FPL owners, with 287,000+ (6.7%) trusting the striker with the Gameweek captaincy.
He had produced returns in all of his previous five starts, supplying seven goals and three assists.
It was a similar story for Eriksen. He claimed 39,000 new Gameweek owners following two goals and four assists from his last five outings.
Meanwhile, Dele Alli (£9.2m) had supplied points in eight of his previous nine Gameweeks, delivering six goals and four assists.
Friday's blank for the trio casts doubts over their likely output over their remaining three fixtures.
With a top-four spot assured, Kane's 19.7% ownership will hope that the striker's quest for the Golden Boot will assure continued goal returns.