De Roon contributed four recoveries and four clearances, blocks and interceptions (CBI) to tally 32 in the Bonus Points System (BPS).
He also made 13 recoveries to score 30 in the BPS.
Friend gained from winning three tackles, while Gibson registered seven CBIs.
The Boro midfielder had two shots, including his decisve strike from inside the box.
Khazri recorded a Creativity score 44 made up of three successful crosses, creating two scoring chances for the visitors at the Riverside Stadium.
Despite failing to score for a ninth consecutive outing, Sunderland's Jermain Defoe (£7.6m) registered the highest Threat score in Wednesday’s contest with 49.
The striker totalled three shots, with two arriving from inside the penalty area.
Handed the captain’s armband by more than 150,000 managers, Alvaro Negredo (£6.3m) delivered a second successive blank to finish Double Gameweek 34 with only four points.
The Spaniard failed to produce a single shot against the Black Cats and has already been sold by 26,000+ FPL managers.
Negredo was perhaps destined to be a short-term option, with all of Boro’s remaining four fixtures scoring three or more in the Fixture Difficulty Rankings (FDR).
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Investors in Boro’s defence did get some reward, however.
With more than 115,000 new Gameweek 34 owners, Gibson returned seven points over his two fixtures.
But like Negredo, Boro’s defenders look set to suffer from that testing season run-in.
As for Sunderland, they have failed to score in four successive away matches.
That fixture will mark a final opportunity for Defoe to remain in the frame as an FPL asset. Still found in 807,000 (17.8%) squads, he has been sold by more than 266,000 FPL managers over the last four Gameweeks.