The duo scored 32 in the Bonus Points System (BPS), with Mustafi producing a goal and an assist as well as three recoveries and three tackles won.
But Mustafi’s BPS total suffered as he was tackled on three occasions, committed two fouls and received a yellow card.
GW30 Top Point Scorers— FPL (@OfficialFPL) April 3, 2017
15 - Simpson (£4.8m) & Britos (£4.3m)
13 - Coutinho (£8.2m)
12 - Mustafi (£5.2m)
How many of them did you have? pic.twitter.com/2DSsfZb7vE
Utilised in an unfamiliar right-back role, Navas was booked early before adjusting to contribute nine recoveries and eight successful tackles – three more than any other player in Gameweek 30.
The Spaniard also raided forward to provide three open-play crosses, creating three goalscoring opportunities.
Sergio Aguero (£12.7m) collected a single bonus point with 31 in the BPS.
The Argentinian scored Man City’s second goal and completed 86% of 38 attempted passes, supplying two scoring opportunities.
But his BPS total was diminished by being tackled on five occasions, while he also missed a "big chance" for the visitors.
Owned by only 1.3% of FPL managers, Mustafi produced a 12-point haul – his biggest tally of the season – ahead of Arsenal’s run of 10 fixtures in the remaining eight Gameweeks.
Further forward Theo Walcott (£7.3m) scored for the third successive home match in all competitions to suggest he could offer a mid-price midfield option.
Meanwhile, the 27%-owned Alexis Sanchez (£11.6m) produced only a second blank in 10 Gameweek outings.
For Man City, Leroy Sane’s (£7.5m) opener means he has supplied a goal or an assist in five of their last eight Gameweeks.
Aguero has also improved his output, having scored in three of the last four Gameweeks ahead of a midweek trip to Chelsea.
But Raheem Sterling’s (£7.7m) 12% owners will be concerned after he was replaced at the break in a tactical switch.
Rested for the second of City’s Gameweek 27 matches, Sterling is the fifth most-sold midfielder since the weekend deadline passed, suffering more than 12,000 sales.