But is that easier said than done?
We have looked at the worst ever results for each of the current 20 Premier League clubs, and how they fared after that loss.
Since some teams have suffered the same margin of defeat more than once, there have been 26 instances of clubs seeking to bounce back from a record or joint-record loss.
Of those, 12 sides have gone on to lose their next match too. Eight have managed to pick up a point, and only six have been able to respond in the best possible way with a win.
Man Utd will be looking to buck the trend when they host Southampton on Sunday.
And they can take heart from the memories of inflicting Saints' joint-worst defeat in 2020/21, when they triumphed 9-0 at Old Trafford.