But the Foxes are without two key forwards for those encounters. Jamie Vardy is injured and Kelechi Iheanacho is at the Africa Cup of Nations (AFCON) with Nigeria.
That lifts the appeal of midfield duo Harvey Barnes and Ademola Lookman as routes into their attack.
Barnes has two goals and an assist in his last three appearances in all competitions.
Lookman played up front in Leicester's FA Cup win over Watford last weekend, supplying three assists.
As always, the players discussed were owned by under half the managers in eight-team Draft leagues in the previous Gameweek.
The Seagulls also boast a pair of in-form midfielders, with Alexis McAllister scoring twice and earning 15 points in the previous Gameweek while Enock Mwepu has three assists in his last three appearances.
Brighton also have a favourable upcoming schedule after their blank Gameweek 24. From Gameweek 25 onwards, three of their four matches score only two in the Fixture Difficulty Ratings (FDR).
Burnley also have two home matches in Gameweek 22, hosting Leicester and Watford.
All of their first-choice back-four, Matthew Lowton, James Tarkowski, Ben Mee and Charlie Taylor, have largely been ignored by Draft managers.
Lowton has 27 points in his last four matches at Turf Moor, while Tarkowski’s five big chances are more than any other defender in Fantasy.
Kepa Arrizabalaga is set to continue as the Blues’ No 1 against Man City and Brighton in Gameweek 22, with Edouard Mendy at the AFCON with Senegal.
Meanwhile, both Mateo Kovacic and Christian Pulisic offer options in midfield.
Kovacic has two goals and five assists, earning his third double-figure haul of the season against Liverpool last time out.
Pulisic’s total of four big chances in the last five Gameweeks ranks top for Chelsea.
Remember, the Gameweek 22 deadline is at 18:30 GMT on Friday 14 January.