Manchester United are hopeful of having Marcus Rashford and Mason Greenwood fit, but Anthony Martial and Victor Lindelof are doubts out after getting injured on international duty.
Aaron Connolly could feature for Brighton & Hove Albion but Adam Webster (ankle) has been ruled out.
Bruno Fernandes has three goals and one assist in two matches against Brighton.
Man Utd are looking to keep five consecutive Premier League clean sheets for the first time since August 2017.
Brighton are looking to win three consecutive PL encounters for the first time since October 2018.
The Seagulls have never won at Old Trafford in 12 previous visits.
Referee: Mike Dean. Assistants: Darren Cann, Dan Robathan. Fourth official: Chris Kavanagh. VAR: Peter Bankes. Assistant VAR: Matthew Wilkes.
