Sheffield United will again be without Chris Basham, John Egan, Jayden Bogle, Jack Robinson, Jack O'Connell and Sander Berge.
Jack Grealish and Matty Cash are still out for Aston Villa, along with Kortney Hause.
Sheff Utd have lost 10 home league matches this season, only losing more in one season in their entire history, with 11 in the 2010/11 Championship campaign.
However, the Blades have won their last two home league meetings with Aston Villa.
Villa are looking to secure their first league double over Sheff Utd since the 1993/94 season.
Dean Smith's side are looking to keep nine away clean sheets for the first time in a top-flight season.
Referee: Robert Jones. Assistants: Darren Cann, Derek Eaton. Fourth official: Tony Harrington. VAR: Graham Scott. Assistant VAR: Lee Betts.