The Manchester City centre-back claimed a massive 21 points in the 4-0 home win, the highest score for a defender in a Gameweek this season.
Over 110,000 managers have already made the move for Stones ahead of Gameweek 20.
The 26-year-old has yet to play the second match of his Double Gameweek 19, at home against Aston Villa.
Stones needs seven points against Dean Smith’s side to beat the record for the highest-ever haul from a defender in a single Gameweek.
Steve Watson and John Arne Riise each racked up 27 points in 2003/04 and 2004/05 respectively.
Stones's centre-back partner Ruben Dias (£5.8m) also claimed a double-figure return against Palace, combining a clean sheet with an assist and two bonus to return 11 points.
Man City have now produced seven shutouts in their last nine matches, conceding just twice over that run.
And their upcoming schedule looks encouraging for more defensive returns.
According to the Fixture Difficulty Ratings (FDR), each of their three matches over Gameweeks 20 to 22 score just two.
The Spurs forward was also awarded the maximum bonus, returning nine points.
Kane holds a three-point advantage over his team-mate Son Heung-min (£9.7m), the previous leader.
The South Korean supplied an assist at Bramall Lane, taking his total to 139 points for the campaign.
The Scot moved to 86 points ahead of Liverpool's midweek encounter with Burnley at Anfield.
Owners of Mohamed Salah (£12.5m), meanwhile, will be hoping he can return to form against the Clarets on Thursday.
The Egyptian was the most-selected captain for Double Gameweek 19, handed the armband by over 1.27million managers.
But he has now recorded four successive blanks, his most barren run of the campaign.
Part 1: GW19 FPL stats: Salah caps off poor week for top captains
Part 2: GW19 Bonus points: Targett hits top spot
Part 3: FPL Saturday review: Pereira a powerful differential
Part 4: Which players are on or close to suspension?
Part 6: FPL Monday review: Is there value in Aubameyang?
Part 7: FPL Tuesday review: Fixtures boost Maddison's appeal
Part 8: FPL Wednesday review: Stones equals Gameweek record
Part 9: FPL Thursday review: Pope the top-scoring goalkeeper
Part 10: FPL Saturday review: Grealish breaks 100-point barrier