The West Bromwich Albion playmaker was awarded the maximum three bonus points in the 3-2 win at Molineux, bringing in 15 points.
Callum Robinson (£5.4m) has also profited from a recent change of manager.
The forward has started all four of West Brom's matches under Sam Allardyce and produced two assists on Saturday to pick up nine points.
Both Pereira and Robinson have an ownership under 1.0 per cent ahead of the second match of their Double Gameweek 19, at West Ham United on Tuesday.
Wolves’ Willy Boly (£5.4m) was among three other players to also record double figures.
The centre-back played a part in both of his side’s goals, scoring once and supplying an assist to earn 12 points.
And Leicester goalscorers James Maddison (£7.1m) and Harvey Barnes (£6.8m) continued their improved output ahead of their midweek home match against Chelsea.
Maddison has scored in back-to-back Gameweeks for the first time this season, while Barnes has found the net in three of the last four Gameweeks.
Chelsea's Mason Mount (£6.8m), meanwhile, returned 11 points after netting the decisive goal in his side's 1-0 win at Fulham.
Elsewhere, Aaron Cresswell (£5.4m) has climbed to the top of the defender standings in FPL after West Ham’s 1-0 home win over Burnley.
The left-back helped David Moyes’ men claim their third successive clean sheet, also earning two bonus points against the Clarets.
West Ham frontman Michail Antonio (£6.3m) rewarded his huge number of new owners by scoring his first goal since Gameweek 6.
He was the second most-bought player for Gameweek 19, brought in by over 513,000 managers.
Indeed, Antonio was the only forward with a Double Gameweek 19 to find the net over Saturday’s five matches.
Part 1: GW19 FPL stats: Salah caps off poor week for top captains
Part 2: GW19 Bonus points: Targett hits top spot
Part 4: FPL Sunday review: Managers rushing to Stones
Part 5: Which players are on or close to suspension?
Part 6: FPL Monday review: Is there value in Aubameyang?
Part 7: FPL Tuesday review: Fixtures boost Maddison's appeal
Part 8: FPL Wednesday review: Stones equals Gameweek record
Part 9: FPL Thursday review: Pope the top-scoring goalkeeper
Part 10: FPL Saturday review: Grealish breaks 100-point barrier