During this compact season, Fantasy Premier League managers must take into account not only rotation but the absence of players through suspension.
Any player earning five bookings from their side's first 19 Premier League matches will serve a one-match ban in the same competition. Yellow cards are not carried over to the EFL Cup or FA Cup.
Players who accumulate 10 yellow cards in PL matches up to and including their team's 32nd fixture will serve a two-match suspension in the competition.
The threat of an immediate ban remains for just five players, with 17 teams having completed at least 19 fixtures.
Aston Villa pair Jack Grealish (£7.7m) and Matt Targett (£4.7m) are among those at risk on four yellow cards.
Villa play their 19th fixture at Southampton on Saturday, in Gameweek 21, so a fifth booking in that match would trigger a one-match suspension.
Currently no players are suspended for upcoming Premier League matches.
Fulham's Antonee Robinson (£4.4m) is available for selection in Gameweek 21 after completing a three-match ban.
Ryan Bertrand (£5.0m) is back in contention after sitting out Southampton's defeat to Arsenal on Tuesday.
And Abdoulaye Doucoure (£5.2m) is free to return following his one-match suspension for accumulating five yellow cards.