Manager Jurgen Klopp says Jota will be assessed ahead of Sunday's trip to Fulham after he picked up a knock while playing in the UEFA Champions League in midweek.
Jota can be found in 29.5 per cent of squads, making him the fifth most-popular midfielder in the game.
The Portuguese has the form to flourish if he is passed fit. He has scored in four of the last six Gameweeks, totalling 38 points.
But the busy schedule could now persuade many of his owners to look for alternatives.
Liverpool’s Gameweek 13 home match against Tottenham Hotspur takes place on Wednesday 16 December, just three days after their Craven Cottage encounter.
Jack Grealish (£7.7m) is among the standout options for those seeking a Jota replacement.
The Aston Villa playmaker has two goals and three assists in his last four appearances.
Riyad Mahrez (£8.4m), Pascal Gross (£5.8m) and Jarrod Bowen (£6.3m) also offer the ideal combination of form and fixtures.
Remember the Gameweek 12 deadline is at 18:30 GMT on Friday 11 December.