Chelsea are aiming to build on their 4-0 home win over Crystal Palace, while a third consecutive victory for Southampton would take them above their hosts.
Team news
Hakim Ziyech will be in Chelsea's squad for the first time, with Ben Chilwell and Christian Pulisic also available, but Edouard Mendy and Thiago Silva are both ruled out.
Stuart Armstrong (self-isolating) and Moussa Djenepo (hamstring) are set to miss out for Southampton, while Theo Walcott could make his debut after joining on loan.
Did you know?
Chelsea have won seven of their last nine Premier League meetings with Southampton.
The Blues have triumphed in seven of their last eight Premier League home matches, netting 18 goals and conceding just four.
After winning this fixture 2-0 last season, Southampton can record back-to-back league victories at Chelsea for the first time since 1985.
Saints are looking to win three consecutive Premier League matches for the first time since a run of four in May 2016.
Match officials
Referee: Peter Bankes. Assistants: Darren Cann, Mark Scholes. Fourth official: Martin Atkinson. VAR: Mike Dean. Assistant VAR: Peter Kirkup.
