For more on this and all the must-know stats for Matchweek 4, read on. To check out the head-to-head records, click on the fixtures.
Crystal Palace are looking to win their opening two away matches of a PL campaign for only the third time and could become just the second team to win at Old Trafford and Stamford Bridge in consecutive away matches, after Sunderland in 2013/14.
Manchester City have lost only one of their last 31 matches against promoted sides, winning 25, but that sole defeat came last season at a Norwich City side who had come up as Championship winners.
Leicester City are looking to start a league season with four straight wins for the first time ever.
Since the start of 2019/20, Ings has scored the opening goal in a league-high 12 Premier League matches for Southampton.
Liverpool can be the first team in top-flight history to start three consecutive campaigns with four wins in a row.