A win for Liverpool at Aston Villa on Sunday will give the defending Premier League champions yet another top-flight record.
For more on this and all the must-know stats for Matchweek 4, read on. To check out the head-to-head records, click on the fixtures.
Crystal Palace are looking to win their opening two away matches of a PL campaign for only the third time and could become just the second team to win at Old Trafford and Stamford Bridge in consecutive away matches, after Sunderland in 2013/14.
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Dominic Calvert-Lewin can become the first Englishman to score in four straight Premier League matches for Everton since Francis Jeffers in September 2000.
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Manchester City have lost only one of their last 31 matches against promoted sides, winning 25, but that sole defeat came last season at a Norwich City side who had come up as Championship winners.
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Newcastle United's Jeff Hendrick could become only the third player to score for and against Burnley in the competition, after Andre Gray and Danny Ings.
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Leicester City are looking to start a league season with four straight wins for the first time ever.
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Since the start of 2019/20, Ings has scored the opening goal in a league-high 12 Premier League matches for Southampton.
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Alexandre Lacazette can become the first player to score in Arsenal's first four matches of a PL season for seven years, Olivier Giroud being the last to do so.
Wolverhampton Wanderers have not lost at home to Fulham in the league since they were beaten 4-0 in the second division in April 1985, winning nine and drawing three since.
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Tottenham Hotspur head coach Jose Mourinho is looking for a first win in seven away matches against teams he has previously managed (D2 L4).
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Liverpool can be the first team in top-flight history to start three consecutive campaigns with four wins in a row.
