Arsenal have not lost to a side starting the day in the relegation zone since they were beaten 1-0 by West Ham United at Emirates Stadium in April 2007.
Sheffield United are hoping to end a six-match winless streak in the Premier League.
Team news
Dani Ceballos is available after recovering from minor thigh and groin problems. Emile Smith Rowe is now back in full training following a shoulder injury.
Sheff Utd's Jack O'Connell has been ruled out for the rest of 2020/21 after undergoing knee surgery this week. Lys Mousset (toe) remains sidelined.
Did you know?
Alexandre Lacazette can become the first Arsenal player since Olivier Giroud in 2013/14 to score in their first four top-flight matches.
The Gunners are unbeaten in their last 40 Premier League home matches against sides starting the day in the relegation zone (W38 D2).
Sheff Utd can go four top-flight matches against Arsenal unbeaten for the first time since 1965.
The Blades are unbeaten in their last nine league matches in London (W4 D5).
Match officials
Referee: Lee Mason. Assistants: Mark Scholes, Timothy Wood. Fourth official: Robert Jones. VAR: Andre Marriner. Assistant VAR: Peter Kirkup.
