Chelsea are looking for their first victory since the opening weekend, having since lost to Liverpool and drawn with West Bromwich Albion.
Crystal Palace can become just the second team to win at Stamford Bridge and Old Trafford in consecutive Premier League away matches, after Sunderland in 2014.
Team news
Frank Lampard revealed Christian Pulisic is likely to be named among the substitutes with the winger recovering from a hamstring problem.
Hakim Ziyech (knee) still isn't quite ready to make his Premier League debut, while Billy Gilmour is also out.
Gary Cahill, James Tomkins and Patrick van Aanholt are all back in training for the Eagles, but this match comes too soon for the trio.
Jeffrey Schlupp remains sidelined with a muscle injury.
Did you know?
Chelsea can secure a sixth successive league win over Palace for the first time.
The Blues have the best win ratio of any team in Premier League London derbies, winning 132 of 256 such matches, or 51.6 per cent.
Palace are aiming to win their opening two Premier League away matches of the season for only the third time.
Wilfried Zaha has been involved in six goals in his 12 Premier League matches against Chelsea, with three goals and three assists. It is his joint-best total against an opponent in the competition.
Match officials
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: Darren England. VAR: Andre Marriner. Assistant VAR: Stephen Child.