Manchester United will keep the pressure on Chelsea for a top-four spot if they win their second Premier League Manchester derby of the season.
Manchester City come into this fixture after reaching the FA Cup quarter-finals in midweek, just four days after winning the EFL Cup for a third consecutive time at Wembley.
Team news
Man Utd's Harry Maguire (ankle), Aaron Wan-Bissaka (back) and Daniel James (knock) are doubtful and will be assessed ahead of Sunday's contest.
Marcus Rashford, Paul Pogba and Lee Grant remain sidelined for the Red Devils.
A decision on Kevin De Bruyne's availability will be made on Sunday and he could be in contention for Man City.
Leroy Sane continues to work his way towards full fitness, but this match comes too soon.
Did you know?
Man Utd are aiming to complete a Premier League double over Man City for the first time since 2009/10 when Sir Alex Ferguson was manager.
With Premier League and EFL Cup victories over Man City in 2019/20, Man Utd can win a third match against them in the same season, a feat they have achieved three times previously in 1956/57, 1995/96 and 2009/10.
Sergio Aguero has scored nine times in Manchester derbies in all competitions. Only Wayne Rooney (11), Joe Hayes (10) and Francis Lee (10) have netted more. Aguero has struck four times in Premier League fixtures at Old Trafford, with Steven Gerrard the only visiting player to score there more often in the competition, with five goals.
Man City have won their last three Premier League matches at Old Trafford and could become the first top-flight side to win four in a row since they themselves did so with a run of five victories between 1968 and 1972.
Match officials
Referee: Mike Dean. Assistants: Darren Cann, Dan Robathan. Fourth official: Anthony Taylor. VAR: Andre Marriner. Assistant VAR: Nick Hopton.