Leaders Liverpool are aiming to extend their unbeaten home league run to 51 matches and move back 13 points clear of second-placed Leicester City.
Sheffield United are looking to avoid a second successive away defeat, having been unbeaten all season on the road until their last outing at Manchester City.
Liverpool's Xherdan Shaqiri has been ruled out with a hamstring injury but Jurgen Klopp has reported no new injury concerns.
Fabinho, Dejan Lovren, Joel Matip and Alex Oxlade-Chamberlain all remain sidelined for the Reds.
Sheffield United will monitor John Lundstram (ankle) to see if he has any reaction after returning to training on Tuesday.
The Blades report no new injury issues ahead of the Anfield contest.
Under Jurgen Klopp, Liverpool have won all 11 of their home league matches against promoted sides by an aggregate score of 33-4.
The Reds are looking to record a fifth consecutive Premier League clean sheet for the first time since September 2007, when Rafael Benitez was in charge.
Having beaten Everton 2-0 at Goodison Park in September, Sheffield United are aiming to win away against both Merseyside clubs in the same league campaign for the first time since 1965/66, when Liverpool won the league and Everton lifted the FA Cup.
The Blades can become only the fourth promoted team in Premier League history to win away against a team starting the day top of the table, after Ipswich Town at Norwich City in December 1992, Derby County at Manchester United in April 1997 and Hull City at Arsenal in September 2008.
Referee: Paul Tierney. Assistants: Daniel Cook, Harry Lennard. Fourth official: Anthony Taylor. VAR: Kevin Friend. Assistant VAR: Matthew Wilkes.