Jose Mourinho will be looking to end Tottenham Hotspur's run of 12 Premier League away matches without victory after being appointed as their head coach following the departure of Mauricio Pochettino this week.
West Ham United are looking for their first win in seven matches after dropping to 16th.
West Ham's Mark Noble and Michail Antonio trained this week without any problem and could be in contention, says Manuel Pellegrini, who reports no fresh injury concerns. Lukasz Fabianski (hip) is a long-term absentee.
Mourinho is without Erik Lamela (hamstring), Hugo Lloris (elbow) and Michel Vorm (calf), while Tanguy Ndombele (groin) and Jan Vertonghen (hamstring) are doubts for Spurs.
The away team have won five of the last six meetings between these sides in all competitions. Spurs can now win a third consecutive top-flight away match against the Hammers for the first time.
After becoming the first away team to win at the new Tottenham Hotspur Stadium in April, West Ham are looking to secure consecutive league wins over Spurs for the first time since doing the double over them in 2013/14.
Spurs have gone 83 Premier League matches without a 0-0 draw, the third-longest such run after Manchester United (114 matches between May 1999 and May 2002) and Ipswich Town (87 matches between August 1994 and September 2001).
Harry Kane has scored 28 goals in 45 Premier League London derbies. Only Thierry Henry (43), Teddy Sheringham (32) and Frank Lampard (32) have netted more in such matches.
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: Robert Jones. VAR: Andre Marriner. Assistant VAR: Andy Halliday.