Southampton are aiming for a first win in five matches, while relegated Huddersfield Town are bidding to bow out on a high after last weekend's 1-1 draw against Manchester United.
Team news
Ralph Hasenhuttl has confirmed that Angus Gunn will return in goal for Southampton after sitting out the West Ham match. Maya Yoshida (virus) remains unavailable.
Goalkeeper Joel Coleman will make his Premier League debut for Huddersfield, who are without Erik Durm (muscular).
Defenders Mathias Jorgensen (illness) and Chris Lowe (knock) will be assessed.
Did you know?
Southampton are unbeaten in their last four meetings with Huddersfield in all competitions (W2 D2), while they have won one and drawn two of the three Premier League matches.
This will be Saints’ third match this season against a side starting the day bottom of the table and they have won neither of the others, against Newcastle United in October and Fulham in November.
James Ward-Prowse has created the most chances of any player who has yet to provide a PL assist this season, with 47.
Shane Long can become the first Southampton player to score in a fourth successive PL home match since James Beattie in April 2003.
Referee: Lee Probert
Assistants: Andy Garratt, Mark Scholes
Fourth official: Peter Bankes