Sixth-placed Manchester United are unable to finish in the top four but a first win in five matches could take them above Arsenal into fifth.
Relegated Cardiff City are aiming to halt a three-match losing run and finish their campaign on a high.
Team news
Ole Gunnar Solskjaer has hinted that a number of youngsters may feature for Man Utd. James Garner, Dylan Levitt, Arnau Puigmal, Tahith Chong, Angel Gomes and Mason Greenwood have all trained with the senior squad this week.
Jesse Lingard and Antonio Valencia could return from injury, but Romelu Lukaku, Alexis Sanchez and Anthony Martial remain doubtful. Eric Bailly is ruled out with a knee injury.
Cardiff duo Harry Arter (calf) and Victor Camarasa (thigh) are set to miss the trip to Old Trafford.
Did you know?
Man Utd are unbeaten in their last eight league meetings with Cardiff, winning six, since a 3-0 away defeat in November 1960.
United have given more players their Premier League debuts in the final match of the season than any other side, with 11.
Cardiff are looking for their first ever away clean sheet against Man Utd, at the 16th attempt (W3 D6 L6).
The Red Devils have won 18 of their 26 final-day PL matches, more than any other side, and are unbeaten in all such fixtures since 2006/07.
Referee: Jonathan Moss
Assistants: Marc Perry, Mick McDonough
Fourth official: Simon Hooper
