Manchester City are targeting a 14th straight Premier League victory, which would ensure that they finish above Liverpool and retain the title.
Their hosts Brighton & Hove Albion have already achieved safety and are aiming to sign off with a first win in nine top-flight matches.
Chris Hughton has confirmed that Davy Propper (hamstring) and Jose Izquierdo (knee) will both miss out.
Sunday's fixture will be Bruno's final appearance for Brighton after announcing his decision to retire following this weekend's match.
Kevin De Bruyne has recovered from a hamstring injury and could feature for Manchester City.
Fernandinho and Benjamin Mendy (both knee) are sidelined.
Brighton have played more top-flight matches against reigning champions without winning than any other team, after 11 such fixtures (W0 D2 L9).
Man City have won their last four meetings with Brighton in all competitions and have already beaten the Seagulls twice this season, in the PL and FA Cup.
City are unbeaten on the final day of the PL season since 2012/13, when Brighton’s current manager Chris Hughton won 3-2 at the Etihad with Norwich City.
Sergio Aguero needs two goals to match his best ever tally of 33 strikes in a season for City in all competitions, achieved in 2016/17, while one goal would equal his second-best total of 32 in 2014/15.
Referee: Michael Oliver
Assistants: Stuart Burt, Simon Bennett
Fourth official: Paul Tierney