Fifth-placed Arsenal are aiming to avoid a fourth straight Premier League defeat as they bid to leapfrog Chelsea into the top four.
Brighton & Hove Albion, now assured of their Premier League safety are looking for a first win in eight PL matches.
Team news
Arsenal's Aaron Ramsey (hamstring) and Denis Suarez (groin) have been ruled out for the rest of the season.
Hector Bellerin and Rob Holding (both knee), along with Danny Welbeck (ankle), are continuing their rehabilitation but are not yet match-fit.
Jose Izquierdo (knee) and Davy Propper (hamstring) are both unavailable for Brighton. Chris Hughton has an otherwise fully-fit squad to choose from.
Did you know?
Arsenal are unbeaten in their last seven home matches against Brighton in all competitions (W6 D1) and have conceded just one goal in those meetings.
Chris Hughton’s Seagulls can become the first south-coast side to win a PL away match against Arsenal, in the 33rd such meeting (P32 W0 D7 L25).
Arsenal have only lost their final home league match of the season in one of the last 21 campaigns, in 2010/11, and have won the last six in a row.
Pierre-Emerick Aubameyang is one PL goal away from becoming the sixth Arsenal player to score 20 in a campaign, and the first since Alexis Sanchez in 2016/17.
Referee: Anthony Taylor
Assistants: Gary Beswick, Adam Nunn
Fourth official: Graham Scott