The 25-year-old playmaker, who has the most assists (4) of any Premier League player this season, missed his side's 2-0 defeat by Tottenham Hotspur as Pep Guardiola suffered his first defeat as head coach.
But ahead of Saturday’s 3pm kick-off City have confirmed that De Bruyne could feature against the Toffees.
"All of the injured players are much, much, much better," Guardiola told mancity.com. "Some will play tomorrow, some will not."
James McCarthy and Aaron Lennon are doubts for Everton, but Leighton Baines, Phil Jagielka, Darron Gibson and Romelu Lukaku are all fit as Ronald Koeman's charges look to end a six-match winless run against Man City in the Premier League.