Sturridge looks favourite to drop to the bench at Stamford Bridge, with Firmino potentially shifting to a 'false nine' role to accommodate the return of the 28% owned Coutinho.
The Blues head coach has confirmed that David Luiz (£6.0m) will be handed a second debut after returning to the club from Paris Saint-Germain.
David Silva (£8.9m) is a major doubt for Manchester City after missing the UEFA Champions League win over Borussia Monchengladbach through injury.
The City head coach may also consider freshening up his options out wide.
Nolito (£9.0m) was rested in midweek and could be handed a role on the left, with Leroy Sane (£7.8m) vying with Raheem Sterling (£8.3m) for a starting berth on the right having replaced him in City’s last two outings.
Over in the red half of Manchester, Luke Shaw (£5.6m), Antonio Valencia (£5.6m) and Wayne Rooney (£9.0m) were all rested for Manchester United’s UEFA Europa League defeat at Feyenoord and are poised to return away to Watford on Sunday.
Owned by 15% of FPL managers, the Ivorian sustained a knock in midweek and the setback could earn a recall for Chris Smalling (£5.9m), who has yet to make a Premier League start this season.
Mauricio Pochettino could also look to rotation in light of Tottenham Hotspur's UEFA Champions League schedule.
The Argentinian tends to alternate his first XI after European matches, particularly at full-back.
Danny Rose (£6.0m) is making a swift recovery but is expected to miss out again.
Remember the FPL Gameweek 5 deadline is at 7pm BST Friday 16 September