Manchester City start the match in third place, having lost three of their last four PL matches.
Southampton, meanwhile, have lost three of their last five and are three points clear of the relegation places.
Southampton midfielder Pierre-Emile Hojbjerg is available again following suspension.
Forward Michael Obafemi (knock) and midfielder Mario Lemina (stomach) are doubtful.
Man City players Fernandinho (thigh), Vincent Kompany (muscular injury) and Gabriel Jesus (knock) have all returned to training but remain doubts.
Manchester City have won their last four PL fixtures against Southampton by an aggregate score of 12-2. They have never won five in a row against Saints in the Premier League.
After a run of six consecutive clean sheets, Man City have conceded in eight of their last nine Premier League matches.
Southampton have won one of their last 11 Premier League meetings with Man City (D2 L8), winning 4-2 in this exact fixture in the 2015/16 campaign.
Man City's Raheem Sterling has been directly involved in 10 goals in his last 10 Premier League appearances against Southampton (six goals, four assists).
Referee: Paul Tierney
Assistants: Constantine Hatzidakis, Scott Ledger
Fourth official: Lee Probert