Second-placed Manchester City are aiming to return to the Premier League summit, while Crystal Palace will hope they can continue their climb up the table with a first defeat of City in seven attempts.
Man City midfielder David Silva (hamstring) and captain Vincent Kompany (muscular injury) have been ruled out.
Crystal Palace will be without goalkeeper Wayne Hennessey (back), while Martin Kelly (abductor muscle) is unable to play on Saturday.
Man City have conceded only three goals in their last eight PL matches against Crystal Palace, keeping eight clean sheets.
Pep Guardiola's side have won all nine and lost none of their PL home matches this season. There have been just five occasions when a team has started with 10 successive wins in a PL campaign: Newcastle United in 1995/96, Chelsea in 2005/06 & 2014/15 and City in 2011/12 & 2013/14.
Crystal Palace were one of only two teams to keep a clean sheet against Man City in the 2017/18 PL season, earning a 0-0 draw at Selhurst Park. The other team to shut out the champions-elect were Huddersfield Town.
Man City are on the longest unbeaten run of Premier League matches kicking off at 15:00 UK time on a Saturday (W32 D4 L0), winning their last 15 by an aggregate score of 57-7.
Referee: Andre Marriner
Assistants: Scott Ledger, Harry Lennard
Fourth official: Anthony Taylor