Watford are bidding to recover from their defeat at Newcastle United, having won their two previous fixtures, while Southampton are seeking a first victory in eight Premier League matches.
Wesley Hoedt (foot infection) and Mario Lemina (thigh) are doubts for Southampton, although manager Mark Hughes believes Lemina is likely to be available.
Watford's Etienne Capoue is suspended but Troy Deeney is back in contention.
Tom Cleverley has returned to training after being sidelined since January but is not being considered for this match. Daryl Janmaat (knee) and Sebastian Prodl (hamstring) are also out of action.
Only one of Southampton’s 21 home league meetings with Watford has ended in a draw – a 1-1 tie in August 2016. The Saints have won 14 of the encounters to Watford’s six.
Mark Hughes has won his last four Premier League matches against Watford, although all of them came while he was manager of Stoke City.
Southampton’s Nathan Redmond has been involved in five goals in his last four PL appearances against Watford, with four goals and one assist.
Watford’s Abdoulaye Doucoure could become only the third player to score in his first four PL appearances against Southampton after Andrew Cole, who netted in his first five, and Dele Alli.
Referee: Simon Hooper
Assistants: Richard West, Harry Lennard
Fourth official: Andre Marriner