Brighton are looking for their first victory in six Premier League matches while West Ham have two wins from their last three.
Brighton midfielder Pascal Gross (ankle) remains sidelined but Dale Stephens (hamstring) faces a late fitness test.
West Ham are without Carlos Sanchez and Winston Reid, Manuel Lanzini (all knee) as well as Andy Carroll and Jack Wilshere (both ankle). Chicharito could return to the squad (glandular fever) but is unlikely to feature from the start.
West Ham have lost all three of their top-flight visits to Brighton, losing in 1981/82, 1982/83 and 2017/18.
Brighton striker Glenn Murray has scored five goals in his last four league matches against West Ham, including three last season for the Seagulls.
West Ham are looking to secure back-to-back Premier League away wins for the first time since February 2017.
Brighton are yet to lose back-to-back Premier League matches at the Amex Stadium.
Referee: Kevin Friend
Assistants: Matthew Wilkes, Simon Beck
Fourth official: Simon Hooper