Dominic Calvert-Lewin (back) remains out for Everton but Mason Holgate (ankle) has returned to training.
Southampton have no new injury concerns but are again likely to be without captain Steven Davis (Achilles).
Everton have lost only one of their 18 previous Premier League home matches against Southampton (W13 D4), a 0-2 defeat in November 1997.
Southampton are aiming for their first league double over Everton since 1997/98. They won this season's reverse fixture 4-1.
The Toffees have the chance to win three consecutive PL matches for the first time since January 2017, while Saints are looking to secure back-to-back victories for the first time since April 2017.
Everton have won their final league match at Goodison Park in nine of the last 11 seasons, losing against Manchester City in 2013/14 and Tottenham Hotspur in 2014/15.
Referee: Jonathan Moss
Assistants: Eddie Smart, Constantine Hatzidakis
Fourth official: Lee Mason