Arsenal have midfielder Aaron Ramsey and goalkeeper David Ospina available after injury.
Jack Wilshere is doubtful with a minor ankle problem and Henrikh Mkhitaryan (knee) is still out. Santi Cazorla (calf) is a long-term absentee.
West Ham United's injury situation is unchanged. James Collins (hamstring) is not yet ready to return, while Pedro Obiang (knee) is battling to be fit before the end of the season.
Michail Antonio (thigh), Winston Reid (knee) and Sam Byram (ankle) will miss the final matches.
Did you know?
West Ham United have won five Premier League matches at Arsenal, level with Chelsea and Aston Villa. Only Manchester United (eight wins) and Liverpool (seven) have won more Premier League matches at Arsenal.
There have been four hat-tricks scored in PL meetings between these sides: Sylvain Wiltord, Thierry Henry, Andy Carroll and Alexis Sanchez. Only Arsenal v Liverpool, with five, has had more.
West Ham have drawn each of their three away London PL derbies this season. The last time they went unbeaten in all their away London derby matches in a top-flight campaign was in 1983/84 (W1 D2 L0).
Pierre-Emerick Aubameyang has been directly involved in eight goals in his opening eight PL matches for Arsenal (six goals, two assists). Only Andrey Arshavin, with six goals and three assists, has had a hand in more in a player’s first eight appearances for the club.
Club previews
Arsenal: Lacazette's goals and Aubameyang's role
West Ham: Fernandes: West Ham's confidence is growing
Referee: Lee Mason
Assistants: Harry Lennard, Matthew Wilkes
Fourth official: Graham Scott