The Welshman will become only the second man to have managed six different teams in the Premier League.
After leaving Manchester in December 2009, Hughes was next in charge of Fulham, whom he led to qualifying for the UEFA Europa League.
The next season Hughes took over at Queens Park Rangers in January 2012, keeping them up despite an extraordinary 3-2 final-day defeat at the hands of Man City, who clinched the title as a result. He left in November of that year.
Hughes was appointed Tony Pulis's replacement at Stoke City ahead of the 2013/14 campaign, guiding the Potters to ninth place in his first three seasons in charge before his departure in January 2018.
Hughes moves clear of four men who have taken charge of five PL clubs: Harry Redknapp (West Ham United, Portsmouth (twice), Southampton, Tottenham Hotspur, QPR); Alan Pardew (West Ham, Charlton Athletic, Newcastle United, Crystal Palace and West Bromwich Albion) and Roy Hodgson (Blackburn, Fulham, Liverpool, West Brom and Palace).
Only one manager has taken charge of more clubs than Hughes's six.