Manchester United will be without Michael Carrick and Eric Bailly. Zlatan Ibrahimovic, Nemanja Matic and Phil Jones are all in contention.
Manchester City midfielder David Silva is fit to play, but Fabian Delph (illness) is a doubt as is Vincent Kompany.
Did you know?
After losing four Premier League matches in a row against Manchester City, Manchester United have lost only one of their last five derbies against them.
No away side has scored more Premier League goals at Old Trafford than Manchester City (27 - level with Chelsea) while only Chelsea (6) have won more matches there as the visiting side in the competition than City (5).
United are on the longest current unbeaten home run in the Premier League (24 matches - W14 D10 L0), with their last such defeat at Old Trafford coming against Manchester City in September 2016.
If Pep Guardiola's side win this match then they will equal the all-time English top-flight league record of 14 consecutive victories; set by Arsenal between February and August 2002.
What the managers say
Jose Mourinho: "It's a big match against one of the best teams in the country. We are a better team than last year - I think City are also better than last season."
See: Lingard: Manchester needs to be red
Pep Guardiola: "Going to Old Trafford is a pleasure. That’s why we are here. I will enjoy it, definitely. I am looking forward to arriving and playing."
See: Kompay: Derby means more than any other game
Referee: Michael Oliver
Assistants: Scott Ledger, Simon Bennett
Fourth official: Jonathan Moss