AFC Bournemouth manager Eddie Howe says Junior Stanislas (groin) has a "50/50 chance" of returning to the squad.
Southampton defender Cedric Soares has been ruled out with a knock, while Shane Long (calf) will need to be assessed.
Did you know?
Southampton have lost only one of their last nine league fixtures against AFC Bournemouth (W6 D2).
There has not been a draw in the last eight league meetings between these two sides at Vitality Stadium, both teams winning four times.
AFC Bournemouth have won four points from their last three PL matches played on a Sunday. Southampton's only win in their last seven away league matches on a Sunday (D4 L2) was at AFC Bournemouth last season (1-3).
The first of Jermain Defoe’s four PL hat-tricks came against Southampton, for Tottenham Hotspur in December 2004.
What the managers say
Eddie Howe: "We'll enjoy the atmosphere and the rivalry. On Wednesday, we didn't allow the crowd into the game."
See: Howe on Stanislas chances
Mauricio Pellegrino to follow.
Referee: Jonathan Moss
Assistants: Eddie Smart, Harry Lennard
Fourth official: Roger East
