Tottenham Hotspur are without Hugo Lloris (groin), Toby Alderweireld (hamstring), Victor Wanyama (knee) and Erik Lamela (hip).
Harry Kane is available after returning from injury in the midweek UEFA Champions League win over Real Madrid.
Crystal Palace have Mamadou Sakho (calf) and James McArthur (ankle) back in training, though the latter may not be risked.
Patrick van Aanholt (hamstring) has an outside chance of returning but Christian Benteke, Connor Wickham (both knee), Sullay Kaikai and Lee Chung-yong (both muscular) are still sidelined
Did you know?
Tottenham Hotspur have won each of their last four Premier League matches against Crystal Palace, conceding only once, since losing 2-1 in January 2015 at Selhurst Park.
Crystal Palace's only PL win at Spurs came in November 1997, winning 1-0 courtesy of a Neil Shipperley goal.
In 2017, only Liverpool and Spurs (13) have won more points against the "big six" than Crystal Palace (12).
Since Mauricio Pochettino was appointed manager in 2014, Spurs have won more home points in London derbies than any other side (31, W9 D4 L1).
What the managers say
Mauricio Pochettino: "We must be focused, we must use the result [on Wednesday] to lift us and build our confidence."
See: Latest on Lloris and Alderweireld
Roy Hodgson: "They have an exceptional centre-forward who scores with nearly every touch of the ball, but they're no one-man team."
See: Hodgson on Benteke return date
Referee: Kevin Friend
Assistants: Simon Long, Adrian Holmes
Fourth official: Mike Jones
