Huddersfield Town striker Steve Mounie is in contention after returning to training.
Collin Quaner (calf) is still not fit and Philip Billing (ankle) is ruled out. Kasey Palmer (hamstring) is still not fit.
Manchester United have reported no fresh injury concerns, with Marcus Rashford fit after limping off in midweek.
Did you know?
This will be the first meeting between these sides since the 1971/72 top-flight season, with Manchester United winning both games that season.
The Red Devils are unbeaten in their last 10 league matches against Huddersfield (W7 D3 L0), since a 2-3 away defeat in March 1952.
Man Utd could become the first team in top-flight history to keep eight clean sheets in their first nine matches of a season.
Jose Mourinho has lost two of his 39 previous PL matches against newly-promoted sides (W33 D4), though Romelu Lukaku has failed to score in 17 of his last 24 matches against newly-promoted teams.
What the managers say
David Wagner: We are against one of the biggest clubs in the world and we will create one of the best football atmospheres.”
See: Hogg: We will give it our all
Jose Mourinho: “The place will be buzzing, the people will be happy to have a big club playing in their city, in their stadium, and it will be a big motivation for them."
Referee: Lee Mason
Assistants: Harry Lennard, Matthew Wilkes
Fourth official: Kevin Friend
