The top-scoring FPL asset, Sanchez has notched only one goal in his previous three Gameweek appearances.
But the Chilean’s 27.5% owners will be confident ahead of Wednesday's match.
A 23-point haul against the Hammers back in Gameweek 14, courtesy of three goals and an assist, is the biggest tally by a single player this season.
Owned by 27.2% of FPL managers, the Manchester United forward has produced more shots (71) and shots on target (29) at home than any player this season.
Romelu Lukaku (£10.5m), the top owned asset and top-scoring FPL forward, will share a pitch with Ibrahimovic.
But he faces a tough task in breaking down a home defence that has conceded only one goal in their last four home outings. The Belgian has scored once in his previous six away fixtures, with only two of his last 12 goals arriving on the road.
Jamie Vardy (£10.0m) and Riyad Mahrez (£9.0m) also demand consideration as Leicester City welcome Sunderland to the King Power Stadium.
The most-sought after striker in the Gameweek, Vardy has been acquired by 108,000+ FPL managers on the back of four goals and two assists in the last four matches.
Mahrez, meanwhile, has produced more shots (11) and shots on target (eight) than any team-mate since the appointment of Craig Shakespeare and has netted in two of the last three Gameweeks.
Elsewhere, Liverpool midfield pair Philippe Coutinho (£8.3m) and Roberto Firmino (£8.5m) host AFC Bournemouth at Anfield. Eddie Howe's side have the third-worst away defensive record in the Premier League, conceding 31 goals from 15 matches.
With Sadio Mane (£9.5m) sidelined due to a knee problem, Coutinho has emerged as the top transfer target for FPL managers. He will take 171,000+ new owners into the Cherries meeting following his goal and assist in Saturday's Merseyside derby.
But Firmino has been a more explosive option at Anfield, producing double-digits in front of his own supporters on five occasions.
Now boasting a 30.9% ownership, Alli has risen to joint-second in the midfield standings on the back of three goals and an assist in his last four outings.
While Eriksen has been less consistent, with a goal and two assists in his previous eight Gameweeks, the Dane has still registered eight double-figure hauls ahead of the Liberty Stadium trip.
Although Costa failed to net against the Eagles, the Spain international’s total of eight shots on goal was more than any player in Gameweek 30.
The visitors’ Sergio Aguero (£12.7m) offers an in-form alternative. Having scored in three of his last four appearances, the Argentinian will be backed to breach a Blues defence that has failed to keep a clean sheet in seven successive Gameweeks.