There will be crucial battles up and down the Premier League table in Matchweek 25.
Elland Road will be the site for a major relegation tussle between Leeds United and Southampton, two clubs with transitioning managerial situations.
The match will be the first for Leeds with their new manager Javi Gracia in charge and he will look to reverse their recent fortune that has seen them fall into the relegation zone.
Gracia's first squad will likely feature the American trio of Tyler Adams, Weston McKennie and Brenden Aaronson.
Southampton has yet to appoint a new permanent boss but interim manager Ruben Selles led them to a massive 1-0 victory over Chelsea.
Saints are still bottom of the table but will look to this match as a key opportunity to climb out of the relegation zone.
After briefly reclaiming top spot, Manchester City tumbled back down to second after a 1-1 draw at Nottingham Forest last week.
Pep Guardiola's side now travel to AFC Bournemouth in another key road match in their title race. With the Cherries sitting in 17th place, Man City would love all three points to maintain pace with Arsenal.
AFC Bournemouth pulled off a huge 2-1 road win at Wolverhampton Wanderers last week and will look to keep that momentum going when they return home on Saturday.
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All eyes are on the lone match on Sunday as Tottenham Hotspur host Chelsea for another London derby.
Spurs leapfrogged Newcastle United last weekend after defeating West Ham United to reclaim fourth place in the table but now the challenge will be holding on to that spot.
The first obstacle for them is Chelsea. The Blues were defeated at Stamford Bridge last week by Southampton but are always dangerous with their talent-laden squad.
Lock in for this one. Watch the match on USA Network at 8:30 AM ET.
