Pep Guardiola's side are the favourites to retain the title, sitting one point above the Reds and with a superior goal difference ahead of Sunday's finale.
Intriguingly, their visitors are managed by Liverpool legend Steven Gerrard, who could play a key role in securing the Premier League Trophy for his former club.
If Villa get a point or more, the door will be open for Liverpool, for whom a home victory over Wolverhampton Wanderers would give them their second Premier League title.
This will be the ninth time that the race has been decided on the final day, with the last two also involving Man City and Liverpool.
The omens are on City's side as the teams who have been top at the start of the day on all eight previous occasions have gone on to lift the trophy.
Relive the drama from those thrilling finales below.
1994/95: Blackburn triumph in dramatic day
1995/96: Man Utd triumph in style
1998/99: Cole's chip rescues Man Utd after scare
2007/08: Ronaldo hits 31 as United make it 10
2009/10: Eight-goal Chelsea end United's reign
2011/12: Aguero leaves it late to save Man City
2013/14: Man City pip Liverpool with perfect finish
2018/19: City survive scare to retain title