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Southampton are without a win in 10 home league matches against Manchester United (D4 L6), despite taking the lead in six of them.
Adam Armstrong can become the third player to score in his first two Premier League matches for Southampton, after Manolo Gabbiadini in 2017 and Henri Camara in 2005.
If they avoid defeat, Man Utd would equal Arsenal's top-flight record of 27 successive unbeaten away matches, set between April 2003 and September 2004.
Man Utd beat Southampton 9-0 in February, the joint-biggest Premier League victory in history.
Match officials
Referee: Craig Pawson. Assistants: Ian Hussin, Richard West. Fourth official: Jarred Gillett. VAR: Andre Marriner. Assistant VAR: Lee Betts.
