As the number of vaccinations against COVID-19 grow in the United Kingdom, the NHS needs more assistance in facilitating this vital work.
Some 20 Foundation staff assisted NHS professionals at the Royal South Hants Hospital, where over 1,000 Southampton residents received their vaccination against coronavirus.
The Foundation staff used their expertise from their regular work in their community to guide the recipients of the vaccine, most of whom were aged 80 or over, through the clinic.
"We're all very grateful for the work of the NHS during this pandemic, so it's an honour to be able to help out where we can," head of Saints Foundation, Greg Baker, told the club's official website.
It is the latest step of the increasing co-operation between the Foundation, Southampton and Solent NHS Trust.
Foundation volunteers had helped at one of the first courses of vaccinations in the city last month and Southampton have partnered with the Trust to pool their expertise to promote health and wellbeing across the local community.
Other Premier League clubs have also announced partnerships with their local NHS trusts since the latest lockdown was announced.
Tottenham Hotspur, Leeds United, Crystal Palace and Manchester City are allowing their stadiums or facilities to be used as vaccination centres, while hotel rooms at Chelsea's Stamford Bridge are again being offered to NHS staff at the local hospital.