Manchester City are looking to record back-to-back Premier League victories for the first time this season, while a third consecutive win for Liverpool would take them eight clear of their rivals.
Sergio Aguero, Fernandinho and Benjamin Mendy (all muscle) remain sidelined for Man City.
Gabriel Jesus is in contention, however, after marking his return from injury with a goal against Olympiakos in the UEFA Champions League on Tuesday.
Diogo Jota took a slight knock in Liverpool's Champions League midweek win in Atalanta but is expected to be fit.
Thiago Alcantara, Alex Oxlade-Chamberlain and Fabinho remain sidelined along with long-term absentee Virgil van Dijk.
Man City have won their last three home league matches against Liverpool by an aggregate score of 11-1. They have not won four consecutive home matches against the Reds since March 1937.
Pep Guardiola has lost eight matches against Liverpool's Jurgen Klopp, more than he has any other manager in his career.
Liverpool are looking to keep their first clean sheet in 11 league outings at Man City having conceded 26 goals during the previous 10 (W1, D2, L7).
Diogo Jota's three PL goals for Liverpool this season have been as a substitute – no other player has scored more than once from the bench in the competition this term.
Referee: Craig Pawson. Assistants: Lee Betts, Richard West. Fourth official: Andre Marriner. VAR: Paul Tierney. Assistant VAR: Stephen Child.