Jamie Vardy has made a strong start to the season for Leicester City and will look to continue his excellent record against Manchester City on Sunday.
For more on this and all the must-know stats for Matchweek 3, read on. To check out the head-to-head records, click on the fixtures.
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Manchester United can get a fifth away Premier League win in a row without conceding, a feat not achieved by any club in the competition since they did so in 2011.
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Everton are looking to win back-to-back Premier League trips to London for the first time since 2015.
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Chelsea have won their last four league matches versus West Bromwich Albion without conceding a goal.
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Danny Ings has scored 45 per cent of Southampton's league goals since August 2019, netting 24 times.
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This will be the first Yorkshire derby in the Premier League since May 2001, when Leeds United beat Bradford City 6-1.
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Of Premier League fixtures to have been played at least 50 times, only Aston Villa v Liverpool, with 40 per cent, has had a higher percentage of away wins than Tottenham Hotspur v Newcastle United, with 18 out of 50, or 36 per cent.
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Jamie Vardy has scored five goals and assisted one more in his last eight appearances against Man City. He is the only player to score a top-flight hat-trick against a side managed by Pep Guardiola, doing so in a 4-2 Leicester win in December 2016.
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Raul Jimenez has netted three goals in his last three Premier League matches against West Ham United and is looking to score in three top-flight appearances in a row for the first time since November 2019.
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Aston Villa are aiming to open a Premier League campaign with back-to-back victories for just the third time, having done so in 1995/96 and 1999/00.
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Although Arsenal are winless in their last six matches against reigning champions, they have won each of their last three against Liverpool when the Reds were title-holders. Only three top-flight fixtures have had more defeats for reigning champions than the 16 between Arsenal and Liverpool, with the Gunners enjoying 10 such victories against the Merseyside club.