Manchester United kick off their campaign as the Premier League record-holders for the most victories in opening fixtures. They are targeting their 20th such win on Saturday.
Crystal Palace, who triumphed 2-1 at Old Trafford last season, can become just the seventh side to win there in successive campaigns.
Team news
Summer signing Donny van de Beek could be in line for his Premier League debut after featuring in Man Utd's pre-season friendly at Aston Villa.
Paul Pogba has trained this week but Phil Jones and Axel Tuanzebe remain unavailable.
Mamadou Sakho is back for Palace, and Christian Benteke and Connor Wickham trained on Thursday. Jairo Riedewald is due to return to training on Friday.
Roy Hodgson remains without Gary Cahill (hamstring), Nathan Ferguson (knee), James Tomkins (thigh) and Patrick van Aanholt (shoulder).
Did you know?
Man Utd's home defeat last season is the only time they have lost to Palace in 22 Premier League meetings.
Bruno Fernandes has been involved in 20 of Man Utd’s 51 goals in all competitions since his debut in February. He leads the way for both goals (12) and assists (8) for the Red Devils in that time.
Palace can become the first side to go five Premier League matches unbeaten away against the two Manchester sides since Chelsea in October 2014.
Wilfried Zaha is looking to score in consecutive Premier League matches for the first time since November 2019.
Match officials
Referee: Martin Atkinson. Assistants: Lee Betts, Peter Kirkup. Fourth official: Robert Jones. VAR: Jonathan Moss. Assistant VAR: Marc Perry.
