Crystal Palace are aiming to win at home on the opening day of a Premier League campaign for the first time.
Southampton are unbeaten in their last five PL matches on the road and won this fixture 2-0 in January.
Team news
Patrick van Aanholt is back in training but Saturday's match could come too soon for the Eagles defender.
Luka Milivojevic’s return is a timely boost for Roy Hodgson, who also has Martin Kelly available after he was sidelined towards the end of last season.
Southampton midfielder Stuart Armstrong is ruled out after sustaining a quad injury on international duty with Scotland.
Ralph Hasenhuttl reports no other injury concerns for Saints.
Did you know?
Jordan Ayew scored in seven of Crystal Palace’s 11 PL wins last season, netting nine goals in the campaign
Crystal Palace have won three of their 22 PL matches against Southampton (D6 L13), with this the first time they have met on the opening day.
Southampton's nine victories and 31 points on the road were both top-flight records for the club last season and third best in the PL after Liverpool and Manchester City.
With 12 goals and two assists Danny Ings has been directly involved in 14 goals in his last 14 away Premier League starts.
Match officials
Referee: Jonathan Moss. Assistants: Marc Perry, Dan Robathan. Fourth official: Simon Hooper. VAR: Craig Pawson. Assistant VAR: Nick Hopton.