A home win would take Manchester United three points clear of Leicester City in the top-four fight, ahead of their trip to face the Foxes on the final day.
A draw would put West Ham United's Premier League status beyond any remaining doubt, but their goal difference is likely to keep them up anyway. They are at least 13 goals ahead of the two teams who can still equal their points tally.
Team news
Eric Bailly is out for Man Utd after suffering a head injury in the FA Cup semi-final loss to Chelsea. Luke Shaw (ankle) remains a doubt.
Did you know?
David De Gea needs one more clean sheet to surpass Peter Schmeichel’s 112 Premier League shutouts for Man Utd. If he does so, he will have the most of any goalkeeper for the club in the competition.
Since the season resumed, Man Utd have had 97 shots in Premier League, with 39 per cent of those being taken (22) or created (16) by Bruno Fernandes.
West Ham are aiming to win their final away match for the fourth straight Premier League season.
David Moyes can become the first former Man Utd manager to win a top-flight away match at Old Trafford since Dave Sexton in March 1982 with Coventry City.
Match officials
Referee: Paul Tierney. Assistants: Ian Hussin, Darren Cann. Fourth official: Mike Dean. Replacement official: Natalie Aspinall. VAR: Peter Bankes. Assistant VAR: Peter Kirkup.