A draw for Watford would secure their Premier League status if Aston Villa lose to Arsenal in Tuesday's other match.
Hayden Mullins will be in charge of the Hornets after the club parted company with Nigel Pearson on Sunday.
Manchester City will be looking for a response after losing to Arsenal in Saturday's FA Cup semi-final.
Team news
Midfielder Etienne Capoue misses out again for Watford due to a knock.
Gerard Deulofeu (cruciate ligament), Daryl Janmaat (knee) and Isaac Success (Achilles) remain unavailable for the Hornets.
Pep Guardiola has reported no fresh injury concerns. Sergio Aguero (knee) is still sidelined.
Did you know?
After beating Liverpool 3-0 in February, Watford can become the first side to beat the champions and runners-up at home in a season since Manchester United overcame Spurs and Chelsea in 2016/17.
If Man City score four times, they will equal the Premier League record for goals against an opponent in a season, having won 8-0 in the reverse fixture. Blackburn Rovers scored 12 times against Nottingham Forest in 1995/96, and Spurs matched that figure against Wigan Athletic in 2009/10.
Pep Guardiola has made 137 changes to his starting XI in the Premier League this season. Only Man Utd have made more in a campaign, with 144 in 2013/14 and 140 in 2008/09.
Raheem Sterling has been involved in six goals in his last two matches against Watford in all competitions, with five strikes and an assist.
Match officials
Referee: Michael Oliver. Assistants: Stuart Burt, Simon Bennett. Fourth official: David Coote. Replacement official: Lee Venamore. VAR: Paul Tierney. Assistant VAR: Dan Robathan.