Tottenham Hotspur can overtake their local rivals, while Harry Kane can become the highest scorer in the history of this contest, having struck 10 times against Arsenal.
Arsenal have the chance to remain unbeaten in away London derbies in a Premier League season for the first time since 2004/05.
Team news
Jose Mourinho has no fresh injury concerns, but remains without Dele Alli, Japhet Tanganga and Juan Foyth.
Arsenal have no injuries from their match with Leicester but will be without Eddie Nketiah, who is suspended, while Mesut Ozil (back) will be assessed.
Bernd Leno, Gabriel Martinelli, Calum Chambers (all knee) and Pablo Mari (ankle) are all sidelined.
Did you know?
Jose Mourinho and Mikel Arteta are each taking charge of their first-ever north London derby match.
A goal in this match would make Harry Kane the top scorer in the history of this fixture.
Arsenal are aiming to win three consecutive Premier League away matches for the first time since October 2018.
Pierre-Emerick Aubameyang has been involved in four goals in his last three PL matches against Spurs. However, all of these three goals and one assist have come at home.
Match officials
Referee: Michael Oliver. Assistants: Simon Bennett, Daniel Cook. Fourth official: Graham Scott. Replacement official: Darren Blunden. VAR: Paul Tierney. Assistant VAR: Harry Lennard.
