Third-placed Leicester City are seeking their first win in four matches as they look to stay ahead of the chasing pack in the battle for a top-four spot.
The Eagles are aiming for a third consecutive victory at King Power Stadium, which would end a run of back-to-back defeats in the Premier League.
James Maddison (hip) is a doubt for Leicester, who remain without long-term absentee Ricardo Pereira.
Roy Hodgson revealed Christian Benteke is available having recovered from a muscular problem.
Martin Kelly (calf) is likely to remain unavailable for the Eagles while Nikola Tavares, Jeffrey Schlupp and James Tomkins are all ruled out.
Leicester’s 2-0 win at Selhurst Park in the reverse fixture ended a run of four straight league defeats against Palace, having last completed the double over the south London side in their title-winning 2015/16 campaign.
This would be the first Premier League campaign since 2000/01 that the Foxes remain unbeaten in home matches against London sides if they can avoid defeat on Saturday.
Palace have triumphed on their last two league visits to Leicester, winning 3-0 in December 2017 and 4-1 in February 2019.
Eagles winger Wilfried Zaha has been involved in more goals against Leicester (nine) than he has against any other side, producing five goals and four assists.
Referee: Jonathan Moss. Assistants: Marc Perry, Peter Kirkup. Fourth official: Jarred Gillett. Replacement official: Andrew Fox. VAR: Martin Atkinson. Assistant VAR: Adam Nunn.