Norwich City are five points adrift at the foot of the table but their head coach Daniel Farke believes his side can pull off a great escape.
“It’s all in our hands and we have nine games and if we are capable of winning at least five we will stay in the league," he told the club's official website. "It’s still doable and possible."
Southampton, who are 14th, are aiming to complete a top-flight league double over the Canaries for the first time.
Team news
Norwich have confirmed that they will be without defensive players Sam Byram, Grant Hanley and Christoph Zimmermann for the remainder of the season due to hamstring injuries.
Marco Stiepermann has been ruled out but Timm Klose has recovered from knee ligament damage and is available for the first time since August 2019.
Moussa Djenepo serves the first match of a three-match suspension for his red card against Newcastle United last time out.
Southampton have no other confirmed absentees, but Friday's match could be too soon for Shane Long who is nursing a minor muscle strain.
Did you know?
Norwich's Emiliano Buendia has provided seven assists this season, the most in the Premier League by a player yet to score.
The Canaries have lost only one of their seven home Premier League matches against Southampton, a 5-4 defeat in April 1994.
Southampton have won each of their last six encounters against promoted teams.
Danny Ings has scored only once in his last seven Premier League matches, having struck 10 times in his 11 previous top-flight appearances.
Match officials
Referee: Kevin Friend. Assistants: Adrian Holmes, Simon Beck. Fourth official: Dean Whitestone. VAR: Simon Hooper. Assistant VAR: Mark Scholes. Replacement official: Garry Maskwell.