The teams in third and fourth place meet at King Power Stadium with hosts Leicester City aiming to move 11 points clear of Chelsea.
The Foxes ended a two-match losing streak with victory at West Ham United last time out, while Chelsea's late draw with Arsenal leaves the Blues seeking a first win in three.
Leicester striker Jamie Vardy (glute) could be in contention to start. Captain Wes Morgan (groin), however, will be sidelined.
Tammy Abraham (ankle) is being monitored by the Chelsea medical team and a late decision will be made on his availability.
The Blues have no fresh injury concerns, says head coach Frank Lampard.
Leicester are unbeaten in their last four League meetings with Chelsea (W1 D3), their best run since a streak of five between 1999 and 2001.
But Chelsea have won five of their last seven league trips to the Foxes (D1 L1) and no team have won more away PL matches against Leicester at King Power Stadium than their four.
Brendan Rodgers is aiming for his first victory over Chelsea as a manager at the 14th attempt (D7 L6). He has only lost more matches against Manchester United, with nine.
This will be Chelsea's 12th consecutive Matchweek starting the day fourth, the longest run in that position since Tottenham Hotspur began 23 in a row between December 2005 and May 2006. Spurs ended that season in fifth spot.
Referee: Lee Mason. Assistants: Simon Long, Mark Scholes. Fourth official: Oliver Langford. VAR: Graham Scott. Assistant VAR: Andy Halliday.